PROMPT Science Advisory Board

Why a bigger panel raises your odds of a VUS

More genes on a test means more places a question mark can appear. Here’s why panel size drives VUS...

Germline vs somatic variants, explained

What separates an inherited germline variant from an acquired somatic one — and why the distinction...

Advances in multi-gene panel sequencing, and what they mean for screening

How next-generation multi-gene panels read many cancer-risk genes at once, how variants are classifi...

Direct-to-consumer vs clinical genetic testing: what actually differs

DTC kits and clinical genetic tests can both name a gene — but they differ in coverage, accuracy, an...

The precision-medicine workflow, clinic to report

A plain-language walk through how a genetic sample becomes a clinical report — sampling, sequencing...

Sample integrity: what makes a DNA collection kit reliable

What turns a tube of saliva into testable DNA: preservative chemistry, yield, purity, room-temperatu...

How patient registries turn genetic data into clinical guidance

How hereditary-cancer registries pool genetic test results, classify variants, and turn raw DNA data...

What a variant of uncertain significance really means

A VUS is a genetic finding that isn’t yet classifiable as harmful or harmless. Here’s what it means,...

Home Testing Kits

Bulk Ordering Saliva Kits for Hereditary-Cancer Screening Programs

Running a screening program means ordering collection kits by the hundred. Lot consistency, expiry,...

Sample Collection

Vacutainer Selection for Germline Panel Blood Draws

Not every blood tube preserves germline DNA the way your lab’s assay expects. Additive choice and dr...

Precision Medicine

Pedigree Software and Teaching Models for the Counseling Room

A clear three-generation pedigree does more for a frightened patient than any printout. We review th...

Biospecimen Logistics

Shipping DNA Samples: When Ambient-Stable Beats Cold Chain

Stabilized saliva DNA can ship at room temperature for weeks — if it is packaged correctly. Here is...

Lab Consumables

Choosing PCR Plate Formats for a Genetics Bench

Plate format is not a trivial purchase order line. Well count, skirt, and seal chemistry decide your...

Home Testing Kits

CLIA-Certified vs Direct-to-Consumer Hereditary Cancer Kits

A consumer saliva kit and a clinical hereditary-cancer panel can look identical in the box. The diff...

Sample Collection

Oragene Saliva Kits vs Buccal Swabs: A DNA-Yield Reality Check

Saliva stabilization chemistry and a dry cheek swab do not deliver the same usable DNA. We compare y...

Precision Medicine

What the PROMPT Study Taught Us About Multiplex Genetic Testing

The PROMPT registry pooled patients tested across multi-gene panels to learn what variants of uncert...

Conceptualization

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